Guidelines in my recommended diet according to my genetics

DNA kit adntro box

Discover your food intolerances and allergies, how your body metabolizes vitamins and minerals, personalized diets and recommendations and much more with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

There are several genes involved in metabolic pathways that influence the care of our line: the type of metabolism (thermogenesis), appetite (satiety) and the breakdown of triglycerides (lipolysis). Depending on the genetic variants that you present for each of these factors, it is suggested that you follow some guidelines or others in your diet.

  • If you have a slow metabolism, it is suggested that you stimulate the activation of brown fat (the one that burns). Find out how in the personalized suggestions of the DNA test of ADNTRO.
  • If your appetite is high, it is suggested that you have a fractional diet: smaller amounts of food more frequently.
  • If your triglyceride breakdown is slow, it is suggested that you reduce your intake of simple carbohydrates among others.

And why is this? The answer lies in genetics


After you have eaten, your body releases leptin, the satiety hormone. Later, when leptin levels drop, ghrelin, the hunger hormone, is released, signaling you to eat.

The leptin signal must be received by neuronal cells. In people who are overweight or obese, there is usually a high level of leptin in their body, but often the neurons in their hypothalamus do not receive the signal. Some researchers theorize that people can be leptin resistant due to genetic variants that also make people 'hyperphagic' or insatiable (the signal is not received in the brain, even though it is being produced).

There are 3 main genes involved in satiety (regulation of food intake):

  1. MC4R gene: the melanocortin 4 receptor gene plays an important role in food intake, energy balance and weight control. MC4R variants cause obesity by causing hyperphagia (uncontrolled food intake) and decreased satiety.
  2. Gen FTO: the Gen FTO it acts as an RNA demethylase. This means that the protein encoded by the gene FTO it acts to regulate the gene expression of other genes. Variants in the gene FTO express more FTO, possibly altering the Ghrelin mRNA and causing higher levels of ghrelin ("Hunger hormone"). Furthermore, the gene FTO interacts with leptin and increases resistance to leptin.
  3. BDNF gene: is a fascinating growth hormone that performs many functions in our brain. It is important in obesity as it is related to how your brain controls your appetite. Low levels of BDNF result in overeating: "hyperphagic behavior".


Fats are generated from excess carbohydrates consumed. These fats (fatty acids) bind with another molecule (glycerol) generating triglycerides.

People who are overweight or obese tend to have higher than normal triglyceride levels, but just as triglycerides are generated, they are also eliminated. Genetic and environmental factors play a role in this elimination. Let's look at the genetic factor associated with triglyceride metabolism.

The degradation of triglycerides takes place in a metabolic process known as lipolysis in which triglycerides are broken down again into fatty acids and glycerol thanks to the lipases, releasing energy for our body.

Lipoprotein lipase (LPL) is the main enzyme responsible for the breakdown of triglycerides encoded by the LPL gene and regulated by the APOA5 gene. This is why genetic variants in the LPL and APOA5 gene are associated with greater or lesser efficiency of lipolysis, that is, of triglyceride degradation.

Variants in the gene GCKR gene are also associated with increased triglyceride levels due to genetic causes. Scientific studies have allowed the elaboration of a potential explanation in which they suggest that these variants decrease the expression of enzymes involved in glycolysis (metabolic pathway that consumes glucose to generate energy) and overexpress enzymes involved in the lipogenesis pathway and in the production of VLDL (molecules in charge of triglyceride transportation).

For these reasons, if you have low levels of lipolysis (slow fat burning), your genetics predispose you to high levels of triglycerides (an influential factor in obesity).Your body is less predisposed to their breakdown.


The genetic explanation associated with slow metabolism can be found in this article where we tell you about the metabolic pathways involved in the consumption of fatty acids and why it is an influential factor when it comes to taking care of your diet.


Find out what variants your genetics hide and get your personalized dietary suggestions with the dna testing of ADNTRO or uploading your RAW DNA data.

Share this post

More interesting articles

DNA kit adntro box

Discover your food intolerances and allergies, how your body metabolizes vitamins and minerals, personalized diets and recommendations and much more with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Other topics

Start a unique journey inside your DNA

Kind regards from ADNTRO team

Share this post:


Get a 10% discount!

An Investment
for all Life

DNA test with saliva sample
More complete analysis
Ancestry, Nutrigenetics, Traits and Diseases,...
Already genotyped?

If you have taken a test with 23andMe, MyHeritage, and others, you can upload your DNA for free at 23andMe, MyHeritage, and others.

Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and preventionThe results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.



The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease prevention: identifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

integrate genetics into your practice

Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanks, and research organizations.

integrate genetics into your practice


Specialized for dermatological clinics, this service provides information on dermatogenomics: skin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

integrate genetics into your practice

Fitness and wellness centers

Genetic analysis allows for the design of personalized training programs that, taking into account genetic characteristics focused on the world of sports, such as muscle fiber types and predisposition to injuries, maximize performance and reduce the risk of injuries. Additionally, by considering genetic factors related to sleep and longevity, recommendations can be offered for a healthy and sustainable lifestyle.

integrate genetics into your practice

Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerances.The results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

integrate genetics into your practice


Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorders, such as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

integrate genetics into your practice