How do we genotype your sample? This is a Global Screening Array

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In ADNTRO, the first step to begin your journey through your DNA is to take a saliva sample. The shows the we send to analyze Eurofins Lab, in Denmarkto, one of the largest genotyping centers in europe. The laboratory analyzes the sample using the technique Global Screening Arrayand provides us with the data that we process at ADNTRO in order to be able to provideyou all the content that you will see in the demo of our website.

How does the laboratory analyze the saliva sample?

In the sample are cells of the wall of the mouth that were washed away by saliva. These cells contain the DNA that will be analyzed by the technique of Global Screening Array.

First, the DNA is extracted through a procedure that breaks the cell membranes and separates the internal components, leaving only the Purified DNA. This DNA will be cloned thousands of times using the technique PCR and replacing the nucelotides natural for a few fluorescently labeled.

Then the DNA will be fragmented into small pieces or regions. These regions include specific genes that will allow us to find out, depending on what SNPs (variants of a nucleotide) have, possible phenotypic characteristics such as eye color, a food intolerance or a specific ethnic origin.

What is a DNA chip in a Global Screening Array?

On the other hand, a solid surface of about 2 x 2 cm called DNA chip. The chip contains 700,000 positions or wells in which a DNA probe for each specific SNP. This is a DNA sequence that corresponds to the part of a gene in which a specific SNP is found. On this chip, with the help of automatic devices capable of depositing very small drops in defined positions, our cloned and fragmented DNA sample is poured and allowed to incubate long enough for the DNA can hybridize.

dna chip

If the sample contains the SNP variant that matches the probe on the chip, the DNA strands will hybridize. In this way, the sample DNA fragment is bound to the probe. As the probe is fixed to the plate, we can wash the chip and the sample fragment will not be removed, unless it does not contain the SNP variant of the probe, in which case it will be eliminated with the wash as it has not hybridized.

After incubation and washing, It's analized the chip with a machine capable of recognizing fluorescence in all positions. Those that contain the hybridized sample DNA fragment will be those that have fluorescence while those that have not hybridized, the fragment will have been removed and with it the fluorescence.

fluorescence recognition machine

With this, the Global Screening Array ends, obtaining all the raw data that Eurofins will send us for analysis in ADNTRO. The only thing left is that explore your own DNA in your ADNTRO personal space.

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Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and prevention. The results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.

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Cardio

The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease prevention: identifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

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Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanks, and research organizations.

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Dermatology

Specialized for dermatological clinics, this service provides information on dermatogenomics: skin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

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Fitness and wellness centers

Genetic analysis allows for the design of personalized training programs that, taking into account genetic characteristics focused on the world of sports, such as muscle fiber types and predisposition to injuries, maximize performance and reduce the risk of injuries. Additionally, by considering genetic factors related to sleep and longevity, recommendations can be offered for a healthy and sustainable lifestyle.

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Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerances.The results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

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Neuro

Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorders, such as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

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Kind regards from ADNTRO team