Nothing endures but change

DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Genetic predisposition (sometimes also known as genetic susceptibility) is the probability that an individual has to develop a disease due to its genetic component.

Genetic predisposition is determined based on specific genetic variations that are normally inherited from one of the parents. These genetic variations contribute to the development of a disease, but do not directly cause it. Which means that, for the same disease, a group of people with a high genetic predisposition will develop the disease, while another group will not.

genetic predisposition

GWAS studies focus on identifying genetic changes associated with a greater genetic predisposition for a specific disease. Although each associated genetic variant has a small effect, having variations in numerous genes can significantly increase the risk of disease. The combination of these effects generates a metric known as the polygenic score or "polygenic score”Which is expected to serve as a guide in the future to make decisions in the field of health.

This image explains very well the focus of the GWAS studies, the analysis of very frequent variants, with little impact (bottom right). There is a inverse relationship between the impact of a genetic variant (effect size) and the frequency with which we find it in the population (Alelle Freq.), something very logical from an evolutionary perspective (mutations with a great impact, which fortunately are rare)

GWAS studies
Source: Keynotes by Manolis Kellis, MIT Professor

Although a person's genetic component cannot be altered, changes in his or her environment and lifestyle (nutrition) are capable of decreasing or increasing the risk of developing a disease, usually with a greater impact than our genes alone.

The polygenic value can only explain the relative risk of the disease. Why relative? The data used to generate this score comes from large-scale genomic studies. These studies detect variants in the genome by comparing groups with a disease (cases) and healthy groups (control).

That is why the polygenic value compares the risk of a person with the risk of other people, all of them with a different genetic makeup.

However, What can change my risk? There are three main factors to consider:

  1. The advancement of science: The best example is the discovery of new variants. What does this mean? Publication of new studies on a disease or on any other trait. The addition of new variants will change your result, increasing their confidence levels. Another thing that can affect your results is the modification of the weight of each of the variants.
  2. Study size: The number of people included in the study is relevant to increase the confidence levels of the results. And not only that, but the number of people your results are compared to: the higher the better, as the statistical confidence of the results increases.
  3. The distribution of risk: When we assess your relative predisposition (by comparing it to a reference population), how the risk is distributed affects the results.

When we talk about polygenic value we always speak of probability, not certainty, this being a key limitation for its implementation in the clinic (the weakest evidence is found in populations with non-European ancestry).

At ADNTRO, we work every day to improve our algorithms and the information we provide to our customers with our genetic test. For this reason, we think that the trend variable can be really useful for use in Bayesian algorithms as the “a priori” probability (adjusted and normalized).

@adntro We keep your DNA up to date! And remember "Everything changes, nothing remains" (Heraclitus, 3000 BC).

Share this post

More interesting articles

The best DNA test on the market
Corporate news

The Best DNA Test

What is a DNA Test and How Does it Work? DNA tests have become an essential tool to know our roots, our genetic backgrounds, our

Read more "
DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Other topics

Start a unique journey inside your DNA

Kind regards from ADNTRO team

Share this post:

Facebook
Twitter
LinkedIn
WhatsApp
E-mail

Get a 10% discount!

An Investment
for all Life

DNA test with saliva sample
More complete analysis
Ancestry, Nutrigenetics, Traits and Diseases,...
Already genotyped?

If you have taken a test with 23andMe, MyHeritage, Ancestry.com and others, you can upload your DNA for free at 23andMe, MyHeritage, Ancestry.com and others.

Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and prevention. The results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.

nutrition

Cardio

The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease prevention: identifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

integrate genetics into your practice

Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanks, and research organizations.

integrate genetics into your practice

Dermatology

Specialized for dermatological clinics, this service provides information on dermatogenomics: skin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

integrate genetics into your practice

Fitness and wellness centers

Genetic analysis allows for the design of personalized training programs that, taking into account genetic characteristics focused on the world of sports, such as muscle fiber types and predisposition to injuries, maximize performance and reduce the risk of injuries. Additionally, by considering genetic factors related to sleep and longevity, recommendations can be offered for a healthy and sustainable lifestyle.

integrate genetics into your practice

Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerances.The results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

integrate genetics into your practice

Neuro

Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorders, such as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

integrate genetics into your practice