How to interpret the results of SNPedia?

DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

SNPedia is a genetic variations wiki. It contains information on the effects (phenotype) associated with genetic variations (genotype) allowing a quick and easy query about your SNPs.

However, it is important to have certain knowledge on DNA structure to correctly interpret the SNPedia results. DNA is the carrier of genetic information and has two coiled strands. One is called a coding or positive chain ("plus" in SNPedia) and the other is called a non-coding or negative chain ("minus" in SNPedia).

genetic information

Both strands are of complementary character. What does this mean? That what is in the negative chain has to be complementary to what is in the positive chain so that they can unite and give that double helix structure so characteristic of DNA.

However, the DNA is more complex than just two coiled strands, DNA possesses among other things nitrogenous bases (the "little letters" of DNA) inside the helix. Each chain has its nitrogenous bases and they are linked through hydrogen bonds that would act as couplings between the nitrogenous bases to maintain the complete DNA molecule.

If we take DNA as a spiral staircase, the two chains would be the railings and the nitrogenous bases the steps. For these steps not to break, there must be complementarity between the nitrogenous bases. There are four main nitrogenous bases: guanine (G), cytosine (C), adenine (A), and thymine (T). If we have a G in the positive chain, due to the complementarity of bases, we will have a C in the negative chain. If we have a T in the negative chain, we will have an A in the positive chain.

DNA

Therefore, if we search for example for the SNP rs4988235 in SNPedia, we will find that the genotype associated with lactose intolerance is C or CC. If we go back to the ADNTRO we will see that the risk allele for this SNP is G or GG. So, are my genetic variants poorly studied? NO! Pay attention! In this case SNPedia is giving us the allele information on the negative chain ("orientation" in SNPedia), while ADNTRO always gives the information based on the positive chain and as we well know, C is the complementary base of G.

However, we must not forget that SNPedia is a wiki and as such is for collaborative use. It is possible that certain SNPs are not incorporated in the wiki or the information is sometimes a bit confusing. Through SNPedia, in most cases, you will be able to find links to scientific studies related to the phenotype that originates each SNP.

Las fuentes más fiables y las fuentes con la que nosotros trabajamos son los artículos científicos. Descubre lo que llevas ADNTRO con nuestras pruebas de ADN.

Share this post

More interesting articles

DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Other topics

Share this post:

Facebook
Twitter
LinkedIn
WhatsApp
E-mail

Get a 10% discount!

An Investment
for all Life

DNA test with saliva sample
More complete analysis
Ancestry, Nutrigenetics, Traits and Diseases,...
Already genotyped?

If you have taken a test with 23andMe, MyHeritage, Ancestry.com and others, you can upload your DNA for free at 23andMe, MyHeritage, Ancestry.com and others.

Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and prevention. The results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.

nutrition

Cardio

The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease prevention: identifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

integrate genetics into your practice

Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanks, and research organizations.

integrate genetics into your practice

Dermatology

Specialized for dermatological clinics, this service provides information on dermatogenomics: skin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

integrate genetics into your practice

Fitness and wellness centers

Genetic analysis allows for the design of personalized training programs that, taking into account genetic characteristics focused on the world of sports, such as muscle fiber types and predisposition to injuries, maximize performance and reduce the risk of injuries. Additionally, by considering genetic factors related to sleep and longevity, recommendations can be offered for a healthy and sustainable lifestyle.

integrate genetics into your practice

Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerances.The results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

integrate genetics into your practice

Neuro

Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorders, such as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

integrate genetics into your practice

Start a unique journey inside your DNA

Kind regards from ADNTRO team