Main DNA tests in the market

DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Differences between technologies for genetic analysis

When it comes to genomics, we can find different types of technologies that provide different results. Organizing from the less to the more complex technology we can find genotyping, panel of genes, whole exome sequencing and whole genome sequencing.

Genetic testing direct to consumers

Companies such as ADNTRO, 23andMe, MyHeritage, TellmeGen, Ancestry and a few others, base their analysis on genotyping technologies and offer, what is called, direct-to-consumer (DTC) genetic tests that determine differences in genetic complement by comparing the positions of DNA with that of another sample or a reference sequence. It identifies small variations in genetic sequence within populations, such as single nucleotide polymorphisms (SNP).

In order to genotype a DNA array is needed. In this array are found the probes that have the complementary sequence of each polymorphism. The number of genetic variants analyzed change according to the type or DNA microarray. At ADNTRO we analyze 700,000 polymorphisms (SNPs) of your DNA by using the "Global Screening Array" or GSA, from the Illumina company together with genetic algorithms that allow us to impute your results and analyze up to 20M markers. By analyzing those genetic variants, we can provide a polygenic risk score that tells you your genetic predisposition to complex diseases, to metabolize the active principle of medical drugs, to convert beta-carotenes to vitamin A, etc

Clinical diagnostic tests

On the other hand, if we go to the clinical area the approach is different.

If we want to know which genetic variants might have clinical implications, we will need different technologies: gene panels, whole exome sequencing or whole genome sequencing, depending on the medical purpose. The data obtained will get up to the complete sequencing of the genome (Whole Genome Sequencing). We can analyze its complete DNA (3,200,000,000 positions), and together with complex bioinformatic analysis will be a useful information for the doctor for clinical diagnosis. Some companies have this kind of analysis available like Nebula Genomics and also ADNTRO.

Among the direct-to-consumer DNA tests available in the market, which are the best companies to consider?

We will review the different features of each one, analyzing the reports available, their purchase options and prices, if it is possible to load raw data from other companies, if they offer other services and the way the information is presented (design and user experience). At the end of the article, you will find a comparative table summarizing what each company has to offer.

ADNTRO GENETICS

ADNTRO is a Spanish company, founded in 2020. We base the analysis on Y-DNA (Y Chromosome), mtDNA (mitochondrial DNA), really important to identify haplogroups, and autosomal DNA testing using GSA Array technology from Illumina, that extracts 700,000 markers and with the support of genetic algorithms impute to analyze up to 20M markers that let us provide accurate information about predisposition in many areas.

ADNTRO logo
ADNTRO Home-Kit

Genetic Report Categories available:

  1. Ancestry patterns (genetic admixture and Ancestral shape), Genetic origins, composition, Haplogroups, heterozygosity ratio.
  2. Nutrition and personalized guides with dietary recommendations (including predisposition to obesity, food intolerances and allergies).
  3. Fitness and injury risk (sports performance guide).
  4. Personality: Behavioural genetics and other behavioral traits like happiness hormones…
  5. Age Better: (Telomeres length, skin aging, sleep and chronotype)
  6. Level of relatedness between your samples
  7. Other innovative studies: (Reaction to mosquito bite, Pain Scale, Ayurveda…)
  8. Pharmacogenetics: learn how medicaments affect your body (efficacy / toxicity)
  9. Health: predisposition and protection against diseases

Different tests offered and prices:

  • ADNTRO Entry Kit (Ancestry and origins, Nutrition) - 89€.
  • ADNTRO Basic Kit (Ancestry, Nutrition, Sports, Longevity and curious studies) - 99€.
  • Premium Pack ADNTRO (Ancestry, NutritionSports, Longevity and curious studies, Personality, Pharmacogenetics, Protection and predisposition to complex diseases) - 149€.

Access and upload of raw data: you can get your raw data from the platform and upload your raw data from other companies.

WGS, WES: Offers clinical genetic diagnosis

Regular updates of genetic information based on new research: Monthly updates for your genetic information for a year

Report layout: informative with educational approach, user friendly and easy to understand and with recommendations in some areas.

ADNTRO sample report
ADNTRO report example

23andMe

23andMe is one of the first DTC DNA testing companies founded in the United States in 2006. It screens DNA based on Y-DNA (Y chromosome), mtDNA (mitochondrial DNA) and autosomal DNA tests using Illumina Infinium® Global Screening Array and analyze more than 600,000 SNPs.

23andMe logo
23andMe Kit

Genetic Report Categories available:

  1. Ancestry
    • DNA Relative Finder
    • Family Tree Builder
  2. Traits
  3. Wellness reports (only available in the US)
  4. Health Reports (only available in the US)
  5. Pharmacogenetic reports (only available in the US)

Different tests offered and prices:

  • Ancestry and traits - $99
  • Health and Ancestry - $199 (only available in USA)
  • 23andMe+( Health and Ancestry) - 228$ (only available in USA)

Access and upload of raw data: You can get your Raw data from the platform, however it does not accept Raw data from other companies.

WGS, WES: It does not offer clinical genetic diagnosis.

Regular updates of genetic information based on new research: if you purchase their annual subscription model, you get access to updates (only available in the US)

Report layout: Informative and educational approach.

23andMe sample report
23andMe report example

MyHeritage

MyHeritage is a popular consumer DNA testing service focused on family history. It uses llumina's Global Screening Array (GSA) and analyzes around 700000 SNPs.

MyHeritage logo
MyHeritage Kit

Genetic Report Categories available:

  1. Ancestry Origins (MyHeritage Kit and Full Plan)
  2. DNA Relative Finder (Complete Plan)
  3. Family Tree Builder (Complete Plan)
  4. Check Historical Data (Complete Plan)
  5. Photo Tools and Deep Nostalgia TM (Full Plan)

Different tests offered and prices:

  • MyHeritage Kit (Origins and parentage finder) - 89€.
  • Full Plan - 199 €* with 199 € automatic subscription renewed every year

Access and upload of raw data: You can get your Raw data from the platform and upload Raw data from another company.

WGS, WES: Does not offer clinical genetic diagnosis

Regular updates of genetic information based on new research: Only available when purchasing their annual subscription model.

Report layout: Informative

MyHeritage report
Example MyHeritage report

TellmeGen

TellmeGen is a Spanish company founded in 2014 dedicated to personalized genetic analysis and preventive health. Through its genetic analysis platform, the company offers users information about their genetic profile, predispositions to certain diseases and some drug reactions.

Genetic Report Categories available:

  1. Ancestry
  2. Welfare reports
  3. Personal trait reports
  4. Pharmacogenetic reports
  5. Report of genetic predisposition to diseases

Different tests offered and prices:

  • DNA Starter Kit - 89€ - Includes ancestry, wellness and personal traits
  • DNA Advanced Kit - 149€ - Includes all available reports

Access and upload of raw data: You can get your Raw data from the platform and load Raw data from another company.

WGS, WES: It does not offer clinical genetic diagnosis.

Regular updates of genetic information based on new research: Free forever with all your plans.

Report Design: Informative

Example TellmeGen report

Ancestry

AncestryDNA (Ancestry) was one of the first direct-to-consumer DNA testing companies founded in 1983. The company uses an autosomal testing service that analyzes 700,000 markers that provide information about a user's ethnicity.

Ancestry Logo
Ancestry Kit

Genetic Report Categories available:

  1. Origins+ Ethnicity
  2. DNA Matches (Connect with other people who share your DNA)
  3. Personal traits

Different tests offered and prices:

  • Ancestry DNA - 99$
  • World Explorer Membership+Ancestry DNA - 100$ * with 79,95$ automatic subscription renewed every 3 months
  • AncestryDNA® Traits + Full Access Subscription - 199 $ * with automatic subscription renewed every 3 months

Access and upload of raw data: You can get your Raw data from the platform, however it does not accept Raw data from other companies

WGS, WES: Does not offer clinical genetic diagnosis

Regular updates of genetic information based on new research: Information is updated for 3 months and then can be accessed only after subscription.

Report Design: Educational

Ancestry sample report
Example Ancestry report

Comparative table of different DNA tests available on the market

INFORMATION
Ancestry

Genetic makeup
Estimated ancestry
Maternal and paternal haplogroups
Heterozygosity ratio
Neanderthal and Denisovan Ancestry
























±






Nutrigenetics and recommendations

Genetic diets
Intolerances
Vitamins
Minerals
Recommended foods









±











±
±




±
±

Sports/Fitness

Sports performance
Predisposition to injury
Recommended sports






±







±
±


±

Personality

Behavioural Genetics
Predisposition to addictions
Hormones







±







±




Age Better (Skin and Sleep)

Longevity
Sleep reports















Others studies Innovators

Mosquito Bite, Ayurveda, Pain Scale
Play with your DNA-Conway
Entropy of your DNA







±

















Pharmacogenetics

Metabolization by GWAS
CPIC Recommendations















Health

Predisposition to diseases




± (not in EU)






Relationship between samples
Family search engine±
More than 700k markers and Illumina technology
Sample report available
Raw file upload from other companies
WGS, WES available on the platform for clinical diagnostics
Periodic updates±±
Genetic data shared with other companies✅(Glaxo SmithKline)
Price range89$-149$99$-199$89$89$-149$79$-149$
±
AvailableNot availablePartially availableWe do not have
of the information

Conclusion

Currently publicly traded companies like 23andMe or MyHeritage with thousands of employees and years in business objectively have a very high quality ancestry report; however, they have not innovated to extract all possible information from the genetic code. Obviously, this article has been written by the ADNTRO team, but we have made an objective analysis, comparing many factors and we consider ADNTRO to be the best dna test, with the most complete reports in all categories available on the market, with the best educational and easy-to-use platform and with the most affordable price, as a result of our company's vision of democratizing accessibility to the genetic code and giving the opportunity for everyone to learn and get to know each other better.

Share this post

More interesting articles

DNA kit adntro box

Interested in genetics?
Discover everything you can know about your genetic code with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Other topics

Start a unique journey inside your DNA

Kind regards from ADNTRO team

Share this post:

Facebook
Twitter
LinkedIn
WhatsApp
E-mail

Get a 10% discount!

An Investment
for all Life

DNA test with saliva sample
More complete analysis
Ancestry, Nutrigenetics, Traits and Diseases,...
Already genotyped?

If you have taken a test with 23andMe, MyHeritage, Ancestry.com and others, you can upload your DNA for free at 23andMe, MyHeritage, Ancestry.com and others.

Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and preventionThe results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.

nutrition

Cardio

The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease preventionidentifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

integrate genetics into your practice

Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanksand research organizations.

integrate genetics into your practice

Dermatology

Specialized for dermatological clinics, this service provides information on dermatogenomicsskin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

integrate genetics into your practice

Fitness and wellness centers

Genetic analysis allows design customized training programs that, by taking into account sport-focused genetic characteristics such as muscle fiber types and predisposition to injury, maximize performance and reduce the risk of injury. In addition, by considering genetic factors related to sleep and longevity, the following can be offered recommendations for a healthy lifestyle and sustainable.

integrate genetics into your practice

Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerancesThe results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

integrate genetics into your practice

Neuro

Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorderssuch as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

integrate genetics into your practice