What is heritability?

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We have written this short entry to provide a general overview about the concept of heritability and the basis for it in ADNTRO, as a recent addition to the health report, where we provide either (1) “trait heritability” or (2) “SNP heritability”.

The definition of Heritability is “a measure of how much of the variation of a trait can be attributed to variation of genetic factors, as opposed to variation of environmental factors”.

“H” or heritability is a fundamental parameter in genetics. First introduced by Sewall Wright and Ronald Fisher nearly a century ago, it is key to the response to selection in evolutionary biology and to the prediction of disease risk in medicine.

Trait heritability vs SNP heritability

In the case of ADNTRO we make an additional distinction between the heritability of the trait as a whole or to the genetic markers (SNPs) associated with it. This distinction is subtle, but very relevant.

Imagine we assume that our biology can be explained as a function of our genes + our environment*. Genome Wide Association studies (GWAS) are powerful genetic studies that help understand the heritability of specific traits – Using basic yet powerful statistical methods, we can estimate the variability of a phenotype attributable to genetic effects, nonetheless, when we estimate the predisposition to a specific disease only the most relevant SNPs are included in the analysis and therefore the % of heritability “explained” is lower. Basically, at ADNTRO we want to provide this information to help you pounder how big/small is the genetic factor when explaining your predisposition.

To give you a best feel for it, the heritability of a trait such “eye color” is very high (almost 100%) since the proportion of the variation in eye colour within a population explained by the environment or random chance is mostly Zero, but other traits can be surprisingly high or low when compared to our own expectations.

Genetic factors and their contribution to the different traits

Below we can see the comparison between what people think about the heritability of specific traits -grey at the chart- and the results of genetic research -red at the chart (Source: Robert Plomin research) that yield significant discussion on the 2018 paper “The stability of educational achievement across school years is largely explained by genetic factors” (Nature) and that we also explained in another article about his book “Blueprint.” 

Robert Plomin genetic contribution

Sources used by ADNTRO for reported heritability

The main sources used at ADNTRO for the reported heritability have been either based on the original study research (as this studies typically report an estimate of H) and the great site of Neale Lab (http://www.nealelab.is/) who provide statistics for these studies, mosthly based on the UK Biobank data.

Finally, we will like to point out that there are multiple and important nuances to the concept of heritability (broad and narrow definitions, multivariate…) that requires further reading. The Wikipedia article is very well detailed and complete and, in case you will like further reading about it, two additional recommendations; (1) a very nice article about “Who is best at guessing the heritability of traits (men/Women)” written by Pedro De Bruyckere Here. And (2) “Heritability in the genomics era — concepts and misconceptions” (nature).

*Mathematically there is an additional factor to take into account, and this is the Covariance for GxE (the way Genes and environment interact with each other).

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