What is rheumatoid arthritis?

DNA kit adntro box

Discover your genetic predisposition and protection to more than 120 diseases and much more with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Rheumatoid arthritis is a chronic disease characterized by joint pain, swelling and stiffness that eventually leads to loss of joint function.

It is an autoimmune disorder as the immune system attacks the healthy tissues of the joints due to its hyperactivity.

Symptoms of rheumatoid arthritis

Like many other autoimmune diseases, it is characterized by fluctuating disease activity. Patients with this disease present phases of remission in which the disease stabilizes and phases of relapse in which the disease symptomatology worsens.

Among the characteristic symptomatology of rheumatoid arthritis, the following stand out:

  • Swelling, joint pain both at rest and in movement
  • Fatigue and lack of energy
  • Functional loss of joints
  • Joint stiffness especially noticeable in the mornings
  • Loss of appetite
  • Inflammation can be systemic, also affecting the skin, eyes, lungs, heart and blood vessels, among other organs and tissues.

It can affect various joints, but the most frequent are the hands, wrists and feet.

Rheumatoid arthritis

Causes of rheumatoid arthritis

It is a complex and multifactorial condition whose exact causes are still under investigation, although it is recognized that genetic, environmental and immunological factors are involved. Risk factors include:

  • Age: most cases occur in middle age, but it is not a disease exclusive to this age group.
  • Sex: the prevalence of the disease is higher in women (about 0.8%) than in men (about 0.2%) in people over 20 years of age.
  • Smoking: smoking is considered a risk factor, especially if you have a genetic predisposition to develop rheumatoid arthritis.
  • Obesity: not only is it considered a risk factor, but it can also limit the improvement of the disease.
  • Viruses: sometimes certain viral infections can trigger the disease.
  • Stress: not only is it among the risk factors, but it can influence the body's inflammatory response, worsening the symptoms of the disease.
  • Genetics: Genetics can increase the likelihood that your immune system will react to exposure to various environmental factors. Therefore, although genetics does not determine the presence or absence of this disease, it can predispose you to a greater or lesser extent to develop it.

Genetics and rheumatoid arthritis

Over the years, research has identified several genes that are associated with an increased risk of developing rheumatoid arthritis.

Genetics and rheumatoid arthritis
  • HLA-DRB1: This is one of the genes most closely linked to rheumatoid arthritis. It is part of the major histocompatibility complex (MHC) class II, which plays a crucial role in the immune response. Specific variants of this gene are associated with an increased risk of this pathology and may influence the severity of the disease.
  • PTPN22: encodes a protein involved in the regulation of signaling in immune cells. Variations in this gene have been associated with an increased risk of developing several autoimmune diseases, including rheumatoid arthritis.
  • STAT4: This gene is involved in signaling pathways that regulate immune system activation. Variants of the STAT4 gene have been linked to an increased risk of rheumatoid arthritis and other autoimmune diseases.
  • TRAF1C5: The genetic region that includes these two genes, TRAF1 and C5, has been associated with rheumatoid arthritis. Although the exact mechanism is still unclear, alterations in this region could affect the inflammatory or autoimmune response.
  • TNFAIP3: This gene, which is related to the regulation of the inflammatory response, has been implicated in susceptibility to rheumatoid arthritis. Mutations or variants in this gene could play a role in the inappropriate activation of the immune response in this pathology.
  • CCR6: The CCR6 gene encodes a receptor present on certain immune cells, and variations in this gene have also been linked to an increased risk of developing rheumatoid arthritis.

Thanks to the DNA TEST If you are already genotyped, you can find out your genetic predisposition to develop rheumatoid arthritis along with many other diseases, find out and be part of the community! If you are already genotyped, upload your DNA data.

Share this post

More interesting articles

The best DNA test on the market
Corporate news

The Best DNA Test

What is a DNA Test and How Does it Work? DNA tests have become an essential tool to know our roots, our genetic backgrounds, our

Read more "
DNA kit adntro box

Discover your genetic predisposition and protection to more than 120 diseases and much more with the most complete DNA kit.

Use the coupon BLOG10

Already genotyped? Upload your RAW DNA for free!

Other topics

Start a unique journey inside your DNA

Kind regards from ADNTRO team

Share this post:

Facebook
Twitter
LinkedIn
WhatsApp
E-mail

Get a 10% discount!

An Investment
for all Life

DNA test with saliva sample
More complete analysis
Ancestry, Nutrigenetics, Traits and Diseases,...
Already genotyped?

If you have taken a test with 23andMe, MyHeritage, Ancestry.com and others, you can upload your DNA for free at 23andMe, MyHeritage, Ancestry.com and others.

Digestive Medicine

For digestive clinics or physicians. Provides information on the genetic predisposition to develop diseases of the digestive system- such as Chron's, Inflammatory Bowel Disease among many others - as well as intolerances. This supports a possible early diagnosis and prevention. The results of this study are very positive, allowing for more precise and personalized interventions to improve the quality of life of the patients.

nutrition

Cardio

The applicability and importance of the PRSs in cardio is endorsed by the American Heart Association (AHA). The applicability of PRS is made possible thanks to this tool that helps in the cardiovascular disease prevention: identifying patients with a higher genetic risk of developing conditions such as diabetes, thromboembolism, hypercholesterolemia, and coronary artery disease (CAD), among others, enabling early interventions and preventive measures to improve patients' cardiovascular health.

integrate genetics into your practice

Biobanks, Pharmacies and CROs

Access and consultation of genetic data relevant to health and pharmacology. Thanks to this tool, it is possible to know the predisposition of patients to suffer adverse effects and what dose adjustments are necessary for more than 150 drugs, thus improving safety, efficacy and treatment personalization. This information is backed by Stanford University and approved by the FDA and gives solutions for biobanks, and research organizations.

integrate genetics into your practice

Dermatology

Specialized for dermatological clinics, this service provides information on dermatogenomics: skin sensitivities, efficacy of various topical and oral treatments, essential vitamins and minerals for skin health, dermatological conditions, skin types and more data to help you customize your skin care recommendations.

integrate genetics into your practice

Fitness and wellness centers

Genetic analysis allows for the design of personalized training programs that, taking into account genetic characteristics focused on the world of sports, such as muscle fiber types and predisposition to injuries, maximize performance and reduce the risk of injuries. Additionally, by considering genetic factors related to sleep and longevity, recommendations can be offered for a healthy and sustainable lifestyle.

integrate genetics into your practice

Nutri & Fitness

The practical application of nutrigenomics allows you to differentiate yourself from the competition by offering your patients personalized and accurate information on genetic predispositions to food intolerances.The results of this approach allow the design of dietary plans completely adapted to the genetic profile of the patient. This approach makes it possible to design dietary plans completely adapted to the individual needs maximizing results and providing an exceptional and differentiated service in the field of nutrition.

integrate genetics into your practice

Neuro

Very useful for psychiatric clinics and psychological clinics. Provides information on the genetic predisposition to develop nervous system diseases and mental disorders, such as Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and OCD, among others. This supports a possible early diagnosis and prevention of these conditions, allowing for more precise and personalized interventions for improve the quality of life of patients.

integrate genetics into your practice