What to Do with Your Whole Genome Sequencing (WGS) Data?

If you have your whole genome sequencing (WGS) data, you can upload it to ADNTRO and unlock over 287 reports across seven areas: ancestry, nutrition, fitness, longevity, prevention, personality, and fertility. It accepts VCF files from any provider, and results are ready in less than 30 minutes.

Whole genome sequencing (WGS) is no longer reserved for research labs. Companies like Tellmegen, Nebula Genomics, Dante Labs, and Sequencing.com now offer it at increasingly competitive prices.

But once you have your data in hand, the big question arises: what do I actually do with my whole genome sequencing results? If you’ve been searching for where to upload your whole genome data or how to interpret your WGS raw file, you’re in the right place. In this guide, we explain what your file contains, what you can discover, and how to get detailed reports without needing a genetics degree.

What Is a Whole Genome File and What Formats Exist?

When you receive your whole genome sequencing results, you typically get one or more files in these formats:

• VCF (Variant Call Format): the most common format for processed results. It contains the list of genetic variants that differ from the reference genome. This is the file most interpretation platforms accept.
• FASTQ: the raw sequencing data before alignment to the reference genome. These files are very large (tens of GB) and require bioinformatics processing.
• BAM/CRAM: data already aligned to the reference genome. Also large files, typically used in clinical or research settings.

For most people, the VCF file is what you need to interpret your results. It’s the format that platforms like ADNTRO accept directly.

What Can You Discover with Your Whole Genome?

Your whole genome contains information about millions of genetic variants. This is significantly more than what a conventional genotyping test analyzes (which covers hundreds of thousands of variants). With WGS data, you can explore areas such as:

Disease Prevention

Learn about your genetic predisposition to health conditions such as cardiovascular disease, type 2 diabetes, autoimmune conditions, and neurodegenerative disorders. This is not a diagnosis but a risk estimate based on published scientific evidence that helps you make preventive decisions.

Genetic Interactions with Medications

Find out if certain drugs will be more or less effective for you, or if you have an increased risk of side effects. Genes like CYP2D6, CYP2C19, CYP3A4, and many more are analyzed. This is especially useful to share with your doctor before starting a new treatment.

Personalized Nutrition

Your DNA influences how you process nutrients. Discover your predisposition to intolerances (lactose, gluten), your vitamin metabolism (B12, D, folic acid), and which type of diet best fits your genetic profile.

Athletic Performance

Do you have more fast-twitch or slow-twitch muscle fibers? Does your genetics favor endurance or strength? You can tailor your training based on your genetic profile.

Personality Traits

Genetics also influences behavioral traits. Learn about your genetic predisposition to creativity, empathy, risk-taking, and other personality traits backed by scientific research.

Ancestry and Population Genetics

Discover where your ancestors came from, what percentage of your DNA comes from different world regions, your maternal and paternal haplogroups, and how much Neanderthal DNA you carry. With a whole genome, the resolution of these estimates is even higher.

Where Can I Upload My Whole Genome for Interpretation?

Several platforms allow you to upload your data. However, there’s a common issue: most DNA interpretation services only accept genotyping chip files (from 23andMe, AncestryDNA, etc.) and are not compatible with whole genome VCF files.

Here are some options that do accept WGS data:

A key difference with ADNTRO is that it’s the only platform offering more than 287 reports across 7 categories from a single file, with a comprehensive approach: instead of looking at isolated variants, you get a complete profile across seven areas: ancestry, nutrition, fitness, longevity, prevention, personality, and fertility.

I Have a Whole Genome from Tellmegen, Nebula, or Dante Labs. How Do I Upload It to ADNTRO?

If you already have your whole genome VCF file, whether from Tellmegen, Nebula Genomics, Dante Labs, Sequencing.com, or any other provider, you can upload it to ADNTRO in minutes and get the most out of it:

1. Go to the RAW upload page.
2. Sign up with your email address.
3. Select your VCF file (or drag and drop it directly).
4. ADNTRO automatically detects that it’s a whole genome file and processes it.
5. Receive your results in less than 30 minutes.

Your upload gives you access to all ADNTRO areas: ancestry, nutrition, fitness, longevity, prevention, personality, and fertility.

Frequently Asked Questions

Is it safe to upload my genetic data to a platform?

ADNTRO complies with European GDPR regulations. Your data is encrypted and never shared with third parties without your explicit consent. You can request complete deletion of your data at any time.

Do I need genetics knowledge to understand my results?

No. ADNTRO presents results visually and intuitively, with plain-language explanations. It also features GeneAI, an AI assistant that answers your genetics questions in a personalized way.

What if I had a genotyping test instead of WGS?

ADNTRO also accepts genotyping files from companies like 23andMe, AncestryDNA, MyHeritage, Tellmegen, and others. Even without a whole genome, you can upload your file and get results.

How much does it cost?

Uploading your whole genome to ADNTRO costs €99 and unlocks all areas: ancestry, nutrition, fitness, longevity, prevention, personality, and fertility.