{"id":9213,"date":"2022-12-07T14:06:23","date_gmt":"2022-12-07T13:06:23","guid":{"rendered":"https:\/\/adntro.com\/?p=9213"},"modified":"2025-07-28T08:35:38","modified_gmt":"2025-07-28T06:35:38","slug":"imputacion-genetica","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/corporate-news\/imputation-genetics\/","title":{"rendered":"What is genetic imputation?"},"content":{"rendered":"<p class=\" translation-block\"><b>Imputation in genetics refers to statistical inference from unobserved genotypes<\/b> (not extracted in laboratory analysis). And you may wonder, how is it possible to infer the genotype of a variant that has not been analyzed? What is the accuracy of this?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Linkage Disequilibrium<\/h2>\n\n\n\n<p class=\" translation-block\">Genetic imputation is possible thanks to what is known as <b>linkage disequilibrium (LD)<\/b>. When we inherit genetic variants from our parents, we do it in \"blocks\" as some genes do not segregate independently. This means that they are inherited together more than expected.<\/p>\n\n\n\n<p>This occurs to preserve the blocks of <a href=\"https:\/\/adntro.com\/en\/blog\/learn-genetics\/what-is-adn\/\">DNA<\/a> which often have similar and vital functions so that they always go together.<\/p>\n\n\n\n<p>For example, if there is a very high linkage disequilibrium for variants 1 and 23, knowing only the \"letters\" (alleles) of one of the variants, by statistical inference we can infer the alleles of the other variant, since having a very high LD, in most cases, they are inherited together.<\/p>\n\n\n\n<p>Thanks to this phenomenon that occurs in nature, if for example we have analyzed the AA genotype for variant 1, although we have not analyzed variant 23, we can infer by imputation which alleles you will have at that position in the genome.<\/p>\n\n\n\n<p>This is done with specialized genetic algorithms and databases that contain 100% of the genomic information for a large number of individuals giving the imputation a high statistical value.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"970\" height=\"647\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/12\/colorful-helix.jpg\" alt=\"Decoding the genetic code\" class=\"wp-image-9214\" style=\"width:526px;height:351px\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/12\/colorful-helix.jpg 970w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/12\/colorful-helix-300x200.jpg 300w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/12\/colorful-helix-768x512.jpg 768w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/12\/colorful-helix-18x12.jpg 18w\" sizes=\"(max-width: 970px) 100vw, 970px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Reliability and accuracy of genetic imputation<\/h2>\n\n\n\n<p>There is a lot of study, work and effort behind LD and the imputation, giving it extremely high reliability. Such is the confidence in this technology that most research work related to genetic variants uses genetic imputation.<\/p>\n\n\n\n<p class=\" translation-block\">The genetic imputation presents a large number of internal quality controls making this inference extremely reliable (more than 95%), approaching the results obtained in <a href=\"https:\/\/adntro.com\/en\/blog\/corporate-news\/complete-genome\/\" target=\"_self\">whole genome sequencing<\/a>, but with a much lower cost.<\/p>\n\n\n\n<p>In the <a href=\"https:\/\/adntro.com\/en\/\">DNA TEST<\/a> at ADNTRO we use very powerful databases and imputation algorithms that allow us to have a reliability of more than 95%. However, given that it is not an inference with a reliability of 100% and the transparency that characterizes us at ADNTRO, in the event of having one of the variants that define the <a href=\"https:\/\/adntro.com\/en\/blog\/salud\/alzheimer\/\">APOE haplotype<\/a> We would like to inform you of this.<\/p>\n\n\n\n<p>Remember that if you are already genotyped with another company, you can <a href=\"https:\/\/adntro.com\/en\/upload-your-raw-adn-landing\/\">upload your RAW DNA data for free<\/a> to ADNTRO.<\/p>","protected":false},"excerpt":{"rendered":"<p>Imputation in genetics refers to the statistical inference of unobserved genotypes (not extracted in the laboratory analysis). And you may ask, how is it possible to infer the genotype of a variant that has not been analyzed? How reliable is it? Linkage disequilibrium Linkage disequilibrium Genetic imputation is possible thanks to [...]<\/p>","protected":false},"author":8,"featured_media":9214,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[42,425,424,389,428,427,426,20,238],"class_list":["post-9213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-corporativas","tag-adntro","tag-desequilibrio-de-ligamiento","tag-fiabilidad","tag-genetica-2","tag-imputacion","tag-ld","tag-linkage-disequilibrium","tag-snp","tag-variantes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00bfQu\u00e9 es la imputaci\u00f3n gen\u00e9tica? | ADNTRO<\/title>\n<meta name=\"description\" content=\"\u00bfQu\u00e9 es la imputaci\u00f3n gen\u00e9tica? \u00bfC\u00f3mo de fiable es? \u00bfCu\u00e1nto se usa? 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Biotecn\u00f3loga por la Universidad Francisco de Vitoria, donde recibi\u00f3 dos becas de expediente acad\u00e9mico brillante. Estuvo trabajando en un proyecto de investigaci\u00f3n sobre la asimetr\u00eda izquierda-derecha en Newcastle, siendo premiada en la Conferencia del Centro de Investigaci\u00f3n Cardiovascular Trainees Meeting como el mejor p\u00f3ster (2018). Complet\u00f3 un m\u00e1ster en Biolog\u00eda Computacional en la Universidad Polit\u00e9cnica de Madrid. All\u00ed estudi\u00f3 las redes de interacci\u00f3n metab\u00f3lica en el microbioma de pacientes con Enfermedad de Chron y Colitis Ulcerosa en el centro de investigaci\u00f3n CBGP, centro de Excelencia Severo Ochoa (2020). 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