{"id":8986,"date":"2022-10-21T08:03:00","date_gmt":"2022-10-21T06:03:00","guid":{"rendered":"https:\/\/adntro.com\/?p=8986"},"modified":"2025-11-24T12:26:02","modified_gmt":"2025-11-24T11:26:02","slug":"genoma-completo","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/salud\/complete-genome\/","title":{"rendered":"Whole genome sequencing"},"content":{"rendered":"<p>Whole genome sequencing (WGS) provides a comprehensive picture of your DNA. It's ideal for discovery applications, and has become faster and cheaper than ever before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What is whole genome sequencing?<\/strong><\/h2>\n\n\n\n<p class=\" translation-block\">WGS is a technique used to <b>determine the complete set of genes<\/b> in a given species. It includes both protein-coding sequences and regulatory regions such as promoters, enhancers, and terminators. WGS allows researchers to <b>identify mutations associated with disease and how genomes are organized<\/b>. This information helps us understand the biology of life and learn about our place within it.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn-1024x683.jpg\" alt=\"DNA\" class=\"wp-image-8990\" style=\"width:410px;height:272px\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn-1024x683.jpg 1024w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn-300x200.jpg 300w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn-768x512.jpg 768w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn-18x12.jpg 18w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/adn.jpg 1260w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><strong>How does genome sequencing work?<\/strong><\/h2>\n\n\n\n<p>The basic steps involved in genomic sequencing include the<strong> isolation of DNA from cells, amplification of DNA, preparation of sample libraries<\/strong> for the sequencing of <em>next-generation sequencing<\/em> and analysis of the sequences produced. For example, researchers can use WGS to analyze pathogenic genetic variants among other genetic markers.<\/p>\n\n\n\n<p>Any human biological sample (saliva, hair, blood sample...) containing DNA can be used to obtain a complete genome sequence. Even if the sample is extremely small, it can be used to generate a complete genome sequence.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"453\" height=\"328\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/WGS-workflow.png\" alt=\"Whole genome sequencing procedure\" class=\"wp-image-8987\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/WGS-workflow.png 453w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/WGS-workflow-300x217.png 300w, https:\/\/adntro.com\/wp-content\/uploads\/2022\/10\/WGS-workflow-18x12.png 18w\" sizes=\"(max-width: 453px) 100vw, 453px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What are the benefits of whole genome?<\/strong><\/h2>\n\n\n\n<p class=\" translation-block\">Human WGS is starting to usher in a new era of <b>personalized healthcare<\/b> to improve public health. Genomic DNA is made up of millions of nucleotides (the building blocks of DNA) arranged in a double helix. Using genomic DNA sequencing technology, scientists can <b>sequence the entire genome in an individual<\/b>. This allows them to study how genes interact with one another and what causes disease.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Benefits in health field<\/h3>\n\n\n\n<p class=\" translation-block\">Whole-genome sequencing <b>provides a high-resolution and comprehensive view of the human genome<\/b>. This approach allows you to identify both large and small genetic variations that are difficult to detect with targeted approaches. Additionally, it captures both common and rare variations, including those that may affect disease risk. These advantages make <b>whole-genome sequencing a powerful tool for identifying causal genetic factors underlying complex diseases<\/b> such as cancer.<\/p>\n\n\n\n<p>Whole genome sequencing <strong>provides a complete and high-resolution view of the <a href=\"https:\/\/nam.edu\/programs\/human-genome-editing-initiative\/\" target=\"_blank\" rel=\"noreferrer noopener\">human genome<\/a><\/strong>. This approach allows you to identify large and small genetic variations that are difficult to detect with other approaches. In addition, it captures both common and rare variations, including those that may increase the risk of disease. These advantages make <strong>whole genome sequencing is a powerful tool for identifying the causal genetic factors underlying complex diseases. <\/strong>such as cancer.<\/p>\n\n\n\n<p>There are many potential benefits of whole genome sequencing. For example, <strong>it is possible to identify a child with a genetic disorder<\/strong> or a genetic condition early in life and allow parents to make decisions about whether to pursue prenatal or preimplantation genetic diagnosis.<\/p>\n\n\n\n<p>If a person has a genetic condition, knowing that information can help doctors better understand how the disease progresses and develop more personalized treatments (health care services).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Complete genome price<\/strong><\/h2>\n\n\n\n<p class=\" translation-block\"><a href=\"https:\/\/adntro.com\/en\/whole-genome-sequencing-analysis-prevention\/\" target=\"_self\">WGS<\/a> has allowed scientists to <b>understand the role of specific genes in disease development<\/b>. But there are still some challenges associated with WGS such as costs. When we talk about DNA, WGS is the most expensive genomic technology.<\/p>\n\n\n\n<p class=\" translation-block\">There are <b>other techniques<\/b> that allow us to sequentially analyze small parts of the genome at a lower price point such as <a href=\"https:\/\/adntro.com\/en\/whole-genome-sequencing-analysis-prevention\/\" target=\"_self\">whole exome<\/a> and <a href=\"https:\/\/app.adntro.com\/sign-up\/kit?event_label=header\" target=\"_self\">genotyping<\/a>. These methods make it easier to obtain an understanding of our genetic code.<\/p>\n\n\n<div class=\"wp-block-image is-resized\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1484\" height=\"894\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome.png\" alt=\"\" class=\"wp-image-12577\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome.png 1484w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome-300x181.png 300w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome-1024x617.png 1024w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome-768x463.png 768w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/11\/whole-genome-whole-exome-18x12.png 18w\" sizes=\"(max-width: 1484px) 100vw, 1484px\" \/><\/figure>\n<\/div>\n\n\n<div style=\"height:74px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>To sum up, WGS is a tool for visualizing the human genetic code (the entire genome) at an unprecedented level of detail that captures both large and small variations that might otherwise go unnoticed with targeted methods.<\/p>","protected":false},"excerpt":{"rendered":"<p>Whole genome sequencing (WGS) provides a complete picture of your DNA. It is ideal for detection of genetic variants and has become faster and cheaper than ever before. What is whole genome sequencing? WGS is a technique used to determine the total number of genes in a given species. [...]<\/p>","protected":false},"author":8,"featured_media":8990,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[430],"tags":[42,401,400,402,403,32],"class_list":["post-8986","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud","tag-adntro","tag-exoma-completo","tag-genoma-completo","tag-medicina-personalizada","tag-precio-genoma","tag-salud"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00bfQu\u00e9 es y para qu\u00e9 sirve un genoma completo?<\/title>\n<meta name=\"description\" content=\"En este art\u00edculo podr\u00e1s conocer qu\u00e9 es la secuenciaci\u00f3n del genoma completo, para qu\u00e9 sirve, qu\u00e9 beneficios aporta y su coste\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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Biotecn\u00f3loga por la Universidad Francisco de Vitoria, donde recibi\u00f3 dos becas de expediente acad\u00e9mico brillante. Estuvo trabajando en un proyecto de investigaci\u00f3n sobre la asimetr\u00eda izquierda-derecha en Newcastle, siendo premiada en la Conferencia del Centro de Investigaci\u00f3n Cardiovascular Trainees Meeting como el mejor p\u00f3ster (2018). Complet\u00f3 un m\u00e1ster en Biolog\u00eda Computacional en la Universidad Polit\u00e9cnica de Madrid. All\u00ed estudi\u00f3 las redes de interacci\u00f3n metab\u00f3lica en el microbioma de pacientes con Enfermedad de Chron y Colitis Ulcerosa en el centro de investigaci\u00f3n CBGP, centro de Excelencia Severo Ochoa (2020). Desde el 2020 es Bioinform\u00e1tica en ADNTRO donde desarrolla modelos predictivos, realiza anotaciones y an\u00e1lisis de variantes patog\u00e9nicas, investigaci\u00f3n de literatura GWAS y divulgaci\u00f3n cient\u00edfica.","sameAs":["https:\/\/www.linkedin.com\/in\/sandra-ferreiro-lpez-78804016a\/"],"url":"https:\/\/adntro.com\/en\/blog\/author\/sandra\/"}]}},"_links":{"self":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/8986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/comments?post=8986"}],"version-history":[{"count":16,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/8986\/revisions"}],"predecessor-version":[{"id":18145,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/8986\/revisions\/18145"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/media\/8990"}],"wp:attachment":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/media?parent=8986"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/categories?post=8986"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/tags?post=8986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}