{"id":2247,"date":"2020-12-15T08:42:33","date_gmt":"2020-12-15T07:42:33","guid":{"rendered":"https:\/\/www.adntro.com\/?p=2247"},"modified":"2024-09-23T15:52:50","modified_gmt":"2024-09-23T13:52:50","slug":"como-interpretar-los-resultados-de-snpedia","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/corporate-news\/how-to-interpret-snpedia-results\/","title":{"rendered":"How to interpret the results of SNPedia?"},"content":{"rendered":"<p><a href=\"https:\/\/www.snpedia.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">SNPedia<\/a> is a <strong>genetic variations wiki<\/strong>. It contains information on the effects (phenotype) associated with genetic variations (genotype) allowing a quick and easy query about your SNPs.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>However, it is important to have certain <strong>knowledge<\/strong> on <strong>DNA structure<\/strong> to correctly interpret the SNPedia results. DNA is the carrier of genetic information and has <strong>two coiled strands<\/strong>. One is called a coding or positive chain (&quot;plus&quot; in SNPedia) and the other is called a non-coding or negative chain (&quot;minus&quot; in SNPedia).<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"841\" height=\"473\" src=\"http:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-color.jpg\" alt=\"genetic information\" class=\"wp-image-3411\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-color.jpg 841w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-color-300x169.jpg 300w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-color-768x432.jpg 768w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-color-18x10.jpg 18w\" sizes=\"(max-width: 841px) 100vw, 841px\" \/><\/figure>\n\n\n\n<p>Both strands are of <strong>complementary character<\/strong>. What does this mean? That what is in the negative chain has to be complementary to what is in the positive chain so that they can unite and give that double helix structure so characteristic of DNA.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>However, the <a href=\"https:\/\/adntro.com\/en\/blog\/learn-genetics\/what-is-adn\/\">DNA<\/a> is more complex than just two coiled strands, DNA possesses among other things <strong>nitrogenous bases<\/strong> (the &quot;little letters&quot; of DNA) inside the helix. Each chain has its nitrogenous bases and they are linked through hydrogen bonds that would act as couplings between the nitrogenous bases to maintain the complete DNA molecule.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>If we take DNA as a spiral staircase, the two chains would be the railings and the nitrogenous bases the steps. For these steps not to break, there must be complementarity between the nitrogenous bases. There are four main nitrogenous bases: guanine (G), cytosine (C), adenine (A), and thymine (T). If we have a G in the positive chain, due to the complementarity of bases, we will have a C in the negative chain. If we have a T in the negative chain, we will have an A in the positive chain.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"979\" height=\"1024\" src=\"http:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-composicion-979x1024-1.png\" alt=\"DNA\" class=\"wp-image-3410\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-composicion-979x1024-1.png 979w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-composicion-979x1024-1-287x300.png 287w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-composicion-979x1024-1-768x803.png 768w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/ADN-composicion-979x1024-1-11x12.png 11w\" sizes=\"(max-width: 979px) 100vw, 979px\" \/><\/figure>\n\n\n\n<p>Therefore, if we search for example for the SNP rs4988235 in SNPedia, we will find that the genotype associated with lactose intolerance is C or CC. If we go back to the <a href=\"https:\/\/adntro.com\/en\/\">ADNTRO<\/a> we will see that the risk allele for this SNP is G or GG. So, are my genetic variants poorly studied? NO! <strong>Pay attention!<\/strong> In this case SNPedia is giving us the allele information on the negative chain (&quot;orientation&quot; in SNPedia), while ADNTRO always gives the information based on the positive chain and as we well know, C is the complementary base of G.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"1024\" height=\"349\" src=\"http:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/Comparacion_SNPedia_ADNTRO_lactosa-1024x349-1.png\" alt=\"\" class=\"wp-image-3409\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/Comparacion_SNPedia_ADNTRO_lactosa-1024x349-1.png 1024w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/Comparacion_SNPedia_ADNTRO_lactosa-1024x349-1-300x102.png 300w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/Comparacion_SNPedia_ADNTRO_lactosa-1024x349-1-768x262.png 768w, https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/Comparacion_SNPedia_ADNTRO_lactosa-1024x349-1-18x6.png 18w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>However, we must not forget that SNPedia is a wiki and as such is for collaborative use. It is possible that certain <a href=\"https:\/\/adntro.com\/en\/blog\/learn-genetics\/what-are-snps\/\">SNPs<\/a> are not incorporated in the wiki or the information is sometimes a bit confusing. Through SNPedia, in most cases, you will be able to find links to scientific studies related to the phenotype that originates each SNP.<\/p>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The most reliable sources and the sources we work with are scientific articles. Find out what's in your DNA with our <a href=\"https:\/\/adntro.com\/en\/\">DNA testing<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SNPedia is a wiki of genetic variations. It contains information on the effects (phenotype) associated with genetic variations (genotype) allowing a quick and easy query about your SNPs. However, it is important to have some knowledge about the structure of DNA to correctly interpret the results of SNPedia. DNA is the carrier of information [\u2026]<\/p>","protected":false},"author":8,"featured_media":3411,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[42,69,70,71,72,18,73,51,74],"class_list":["post-2247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-corporativas","tag-adntro","tag-articulos-cientificos","tag-bases-nitrogenadas","tag-complementariedad","tag-estructura-adn","tag-genetica","tag-snpedia","tag-snps","tag-variaciones-geneticas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00bfC\u00f3mo interpretar los resultados de SNPedia? | ADNTRO<\/title>\n<meta name=\"description\" content=\"SNPedia es una wiki de variaciones gen\u00e9ticas y contiene informaci\u00f3n sobre los efectos asociados a las variaciones gen\u00e9ticas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adntro.com\/en\/blog\/corporate-news\/how-to-interpret-snpedia-results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00bfC\u00f3mo interpretar los resultados de SNPedia? 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