{"id":17638,"date":"2025-09-11T06:28:05","date_gmt":"2025-09-11T04:28:05","guid":{"rendered":"https:\/\/adntro.com\/?p=17638"},"modified":"2025-09-16T13:41:08","modified_gmt":"2025-09-16T11:41:08","slug":"linfoma-de-hodgkin","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/salud\/hodgkins-lymphoma\/","title":{"rendered":"Hodgkin's lymphoma: everything you need to know about its genetic predisposition"},"content":{"rendered":"<p>Hodgkin's lymphoma represents one of the most studied hematological cancers in the field of medical genetics. With a worldwide incidence of 0.001%, this disease of the lymphatic system has gained special relevance due to recent advances in the understanding of its genetic and hereditary basis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is Hodgkin's lymphoma?<\/h2>\n\n\n\n<p>Hodgkin's lymphoma is a specific type of cancer that affects the lymphatic system, a critical part of our immune system. Also known as Hodgkin's carcinoma or Hodgkin's disease, this disease is characterized by the presence of distinctive abnormal cells called Hodgkin's lymphoma. <a href=\"https:\/\/www.cancer.gov\/espanol\/publicaciones\/diccionarios\/diccionario-cancer\/def\/celula-de-reed-sternberg\">Reed-Sternberg cells<\/a>formerly known as Hodgkin cells.<\/p>\n\n\n\n<p>The lymphatic system is made up of a network of lymph nodes, lymph vessels and organs that work together to fight infection and disease. When Hodgkin's lymphoma develops, these cancer cells typically originate from B lymphocytes, a type of white blood cell that produces antibodies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Symptoms and clinical manifestations<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Main symptoms of Hodgkin's lymphoma<\/h4>\n\n\n\n<p>The first and most characteristic sign of Hodgkin's lymphoma is the <strong>painless swelling of the lymph nodes<\/strong>especially in the neck, armpits or groin. This neck abnormality is often the initial reason for consultation.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Systemic symptoms (Symptoms B)<\/h4>\n\n\n\n<p>Patients may experience what is medically referred to as a \"<a href=\"https:\/\/www.salud.mapfre.es\/enfermedades\/hematologicas\/sintomas-b-linfomas\/\">B symptoms<\/a>\":<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Persistent fever<\/strong> without apparent cause<\/li>\n\n\n\n<li><strong>Night sweats<\/strong> profuse soaking of bed linens<\/li>\n\n\n\n<li><strong>Unexplained weight loss<\/strong> greater than 10% of body weight in 6 months<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">Other associated symptoms<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><b>Fatigue<\/b><\/strong> extreme and persistent<\/li>\n\n\n\n<li><strong>Pruritus<\/strong> generalized (itching) without visible rash<\/li>\n\n\n\n<li><strong>Dyspnea<\/strong> (difficulty breathing)<\/li>\n\n\n\n<li><strong>Persistent cough<\/strong><\/li>\n\n\n\n<li><strong>Pain<\/strong> in the lymph nodes after alcohol consumption<\/li>\n\n\n\n<li><strong>Edema<\/strong> in extremities<\/li>\n\n\n\n<li><strong>Abnormal bleeding<\/strong> and appearance of <strong>purple<\/strong><\/li>\n\n\n\n<li><strong>Epistaxis<\/strong> (frequent nosebleeds)<\/li>\n\n\n\n<li><strong>Recurrent infections<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Genetics and Hodgkin's lymphoma<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/adntro.com\/en\/blog\/corporate-news\/what-is-heritability-inside\/\">Heritability<\/a> and genetic predisposition<\/h4>\n\n\n\n<p>Recent research has uncovered crucial information about the <strong>genetic predisposition Hodgkin's lymphoma<\/strong>. Scientific studies indicate that the <strong>estimated heritability<\/strong> (a statistical concept that describes how much of the variation in a given trait can be attributed to variation in genetic factors) of this disease is of the <strong>28,4%<\/strong>, while the <strong>heritability explained<\/strong> (a statistical concept that determines how much of the variation in a given trait can be explained by the genetic variants that we know about and can therefore analyze) currently identified is of <strong>24%<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Genes involved<\/h4>\n\n\n\n<p>Genetic research has identified a number of key genes associated with the <strong>predisposition Hodgkin's lymphoma<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><em>TCF3<\/em><\/strong>Transcription factor crucial for the development of B cells.<\/li>\n\n\n\n<li><strong><em>CLEC16A<\/em><\/strong>Related to the function of the immune system.<\/li>\n\n\n\n<li><strong><em>GATA3<\/em><\/strong>Important regulator of cell differentiation<\/li>\n\n\n\n<li><strong><em>LPP<\/em><\/strong>Involved in cell adhesion and migration.<\/li>\n\n\n\n<li><strong><em>AHI1<\/em><\/strong>Associated with neural development and ciliary function.<\/li>\n\n\n\n<li><strong><em>PTPRK<\/em><\/strong>Protein tyrosine phosphatase with a role in cell signaling.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Genetic health test with Hodgkin's Lymphoma<\/h3>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-1024x1024.jpeg\" alt=\"\" class=\"wp-image-16539 size-full\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-1024x1024.jpeg 1024w, https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-300x300.jpeg 300w, https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-150x150.jpeg 150w, https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-768x768.jpeg 768w, https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images-12x12.jpeg 12w, https:\/\/adntro.com\/wp-content\/uploads\/2024\/12\/images.jpeg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong>PREMIUM DNA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Health and prevention<\/li>\n\n\n\n<li>Origins and ancestry<\/li>\n\n\n\n<li>Nutrition<\/li>\n\n\n\n<li>Fitness <\/li>\n\n\n\n<li>Longevity and Skin<\/li>\n\n\n\n<li>Personality<\/li>\n\n\n\n<li>Pharmacogenetics<\/li>\n<\/ul>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-black-color has-pale-cyan-blue-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/app.adntro.com\/sign-up\/kit?kit-selected=ROLE_FULL&amp;event_label=price_card_premium&amp;referrer=&amp;ref=aHR0cHM6Ly9hZG50cm8uY29tL2VzLw%3D%3D&amp;_gl=1*1lekp8k*_gcl_aw*R0NMLjE3MzEwNjc5NzQuQ2owS0NRaUFpcmU1QmhDTkFSSXNBTTUzSzFoT0lLTTQ1bnRFQmFMNURMYUhJZjlsbVNmb2xtS3JBa3lFVWxqQXUteXhxbWRVTlphSXhHRWFBZ0pSRUFMd193Y0I.*_gcl_au*NzgyNjMyNTg5LjE3MzE5MzIwODYuMTcxNzMwNDA2Ny4xNzMzMzA4MTEzLjE3MzMzMDgxMTI.\" style=\"border-radius:100px\">BUY NOW<\/a><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>An <strong>genetic health test including Hodgkin's lymphoma<\/strong> represents a significant advance in preventive medicine. By means of a genetic test, and simply with a saliva sample, it is possible to assess the <strong>genetic protection Hodgkin's lymphoma<\/strong> or individual predisposition to develop this disease.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">How does the test work?<\/h4>\n\n\n\n<p>Genetic testing examines specific variants in the genes associated with Hodgkin's lymphoma. The results can indicate whether a person has Hodgkin's lymphoma:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Increased protection<\/strong> than the population mean<\/li>\n\n\n\n<li><strong>Average risk<\/strong> similar to the general population<\/li>\n\n\n\n<li><strong>Greater predisposition<\/strong> requiring specialized medical follow-up<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Interpretation of your ADNTRO results<\/h4>\n\n\n\n<p>The Hodking's Lymphoma result you can find in the genetic test of <a href=\"https:\/\/claude.ai\/public\/artifacts\/dec2c6d0-9cd0-4b24-81c0-88618a365c23\">ADNTRO<\/a>is based on <strong>3,077 cases<\/strong> and <strong>13,680 controls<\/strong> of European descent, providing a solid basis for the interpretation of results.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Differences between Hodgkin's and Non-Hodgkin's disease<\/h2>\n\n\n\n<p>A crucial distinction in the diagnosis is to understand the <strong>differences between Hodgkin and non-Hodgkin<\/strong>:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Hodgkin's lymphoma:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Presence of Reed-Sternberg cells<\/li>\n\n\n\n<li>Orderly dissemination from node to adjacent node<\/li>\n\n\n\n<li>Better overall prognosis<\/li>\n\n\n\n<li>More common in young adults and older adults<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Non-Hodgkin's lymphoma:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Absence of Reed-Sternberg cells<\/li>\n\n\n\n<li>Random dissemination, can skip lymph nodes<\/li>\n\n\n\n<li>Most diverse group of diseases<\/li>\n\n\n\n<li>Can occur at any age<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">World Hodgkin's Lymphoma Day<\/h2>\n\n\n\n<p>The <strong><a href=\"https:\/\/iob-onco.com\/dia-mundial-del-linfoma\/\">world Hodgkin's lymphoma day<\/a><\/strong>The date, celebrated every September 15, is commemorated to raise awareness of this disease, promote research and support affected patients and families. This date highlights the importance of early diagnosis and advances in treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Evolution and prognosis<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Dissemination patterns<\/h4>\n\n\n\n<p>Hodgkin's lymphoma typically:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Start<\/strong> in one group of lymph nodes<\/li>\n\n\n\n<li><strong>Disseminates<\/strong> in an orderly fashion to nearby lymph nodes<\/li>\n\n\n\n<li><strong>Can be extended<\/strong> to organs such as the lungs, liver or bone marrow<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">Prognostic factors<\/h4>\n\n\n\n<p>The prognosis depends on multiple factors:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Stage of disease at diagnosis<\/li>\n\n\n\n<li>Patient's age<\/li>\n\n\n\n<li>Presence of B symptoms<\/li>\n\n\n\n<li>Levels of certain proteins in the blood<\/li>\n\n\n\n<li><strong>Individual genetic profile<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Implications of personalized medicine<\/h2>\n\n\n\n<p>The understanding of the <strong>genetic predisposition Hodgkin's lymphoma<\/strong> allows:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Targeted screening<\/strong> in high-risk individuals<\/li>\n\n\n\n<li><strong>Preventive strategies<\/strong> recommendations<\/li>\n\n\n\n<li><strong>Specialized monitoring<\/strong> for early detection<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Benefits of genetic analysis<\/h4>\n\n\n\n<p>An <strong>genetic test with information about Hodgkin's lymphoma<\/strong> offers significant advantages:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Early identification<\/strong> of individuals at risk<\/li>\n\n\n\n<li><strong>Medical planning<\/strong> proactive<\/li>\n\n\n\n<li><strong>Peace of mind<\/strong> for people with low predisposition<\/li>\n\n\n\n<li><strong>Valuable information<\/strong> for reproductive decisions<\/li>\n<\/ol>\n\n\n\n<p>Advances in the genetic understanding of Hodgkin's lymphoma mark a new era in preventive medicine. The possibility of knowing our <strong>genetic protection for Hodgkin's lymphoma<\/strong> through specialized analysis represents a powerful tool for informed medical decision making.<\/p>\n\n\n\n<p>Research continues to reveal new genes and mechanisms involved in this disease, promising increasingly personalized prevention and treatment strategies. <\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Hodgkin's lymphoma represents one of the most studied hematological cancers in the field of medical genetics. With a worldwide incidence of 0.001%, this disease of the lymphatic system has gained special relevance due to recent advances in the understanding of its genetic and hereditary basis. What is Hodgkin's lymphoma? The [...]<\/p>","protected":false},"author":17,"featured_media":17641,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[430],"tags":[18,32],"class_list":["post-17638","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud","tag-genetica","tag-salud"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Linfoma de Hodgkin y gen\u00e9tica |\u00a0ADNTRO Genetics<\/title>\n<meta name=\"description\" content=\"El linfoma de Hodgkin representa uno de los c\u00e1nceres hematol\u00f3gicos m\u00e1s estudiados en el campo de la gen\u00e9tica m\u00e9dica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adntro.com\/en\/blog\/salud\/hodgkins-lymphoma\/\" \/>\n<meta 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