{"id":17076,"date":"2025-05-13T12:48:32","date_gmt":"2025-05-13T10:48:32","guid":{"rendered":"https:\/\/adntro.com\/?p=17076"},"modified":"2025-07-24T12:42:47","modified_gmt":"2025-07-24T10:42:47","slug":"trombofilia-factor-v-leiden","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/salud\/thrombophilia-factor-v-leiden\/","title":{"rendered":"Factor V Leiden: what you should know about this hereditary thrombophilia"},"content":{"rendered":"

Did you know that Factor V Leiden is a type of inherited thrombophilia present in approximately 2% of the population?<\/p>\n\n\n\n

What is factor V Leiden and how is it related to thrombophilias?<\/h2>\n\n\n\n

The thrombophilia<\/b> is a condition in which the blood has an increased tendency to form clots, even when there is no obvious injury. These clots, when they form in places where they should not, can cause serious problems such as a deep vein thrombosis in the legs or a pulmonary embolism if the clot travels to the lungs.<\/p>\n\n\n\n

One of the most common causes of hereditary thrombophilia is the factor V Leiden<\/b> a genetic variant of the gene F5<\/em><\/a> which produces a key protein in the coagulation process: the factor V.<\/p>\n\n\n\n

Why is factor V Leiden associated with an increased risk of thrombus?<\/h2>\n\n\n\n

Under normal conditions, the factor V<\/b> is involved in clot formation when a blood vessel is injured. Once the clot has fulfilled its function, another protein in the body, called the activated protein C<\/b> acts as a brake to stop coagulation by deactivating factor V.<\/p>\n\n\n\n

But in people with factor V Leiden<\/b>, this protein has a mutation that causes it to be resistant to the action of activated Protein C<\/b>. As a result, coagulation continues longer than necessary, and that increases the risk of abnormal blood clot formation<\/b>.<\/p>\n\n\n\n

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What does it imply at the genetic level and how useful is it to be tested?<\/h2>\n\n\n\n

The V Leiden factor is due to a point mutation in the gene F5<\/em><\/strong>,<\/em> which encodes the factor V protein. This mutation is hereditary: it is transmitted from parents to children.<\/p>\n\n\n\n

Each person has two copies of this gene, one from each parent. You can inherit:<\/p>\n\n\n\n