{"id":13368,"date":"2024-03-05T08:23:00","date_gmt":"2024-03-05T07:23:00","guid":{"rendered":"https:\/\/adntro.com\/?p=13368"},"modified":"2025-06-16T16:49:52","modified_gmt":"2025-06-16T14:49:52","slug":"gen-mthfr-salud","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gen-mthfr-health\/","title":{"rendered":"What role does the MTHFR gene play in health?"},"content":{"rendered":"

You've probably heard of MTHFR, but do you know what role the MTHFR<\/em><\/b> gene plays in health? The MTHFR<\/em> gene plays a key role in the breakdown (metabolism) of folate or vitamin B9 as well as allowing the creation of a compound (methyl group) necessary for methylation.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
<\/div>\n\n\n\n

What is methylation and what role does the MTHFR gene play?<\/strong><\/h2>\n\n\n\n

Methylation is an essential process that impacts numerous functions of the body. In this article we are going to focus mainly on the elimination of a compound called homocysteine<\/b> and its relationship to the cardiovascular system<\/b>.<\/p>\n\n\n\n

Homocysteine is found in the blood and its increase can trigger adverse health problems, known as hyperhomocysteinemia. This situation is associated with an increased risk of heart disease, such as atherosclerosis, thrombosis and heart disease. Therefore, in order to preserve the health of the cardiovascular system, it is vital to maintain homocysteine levels within a normal range.<\/p>\n\n\n\n

The MTHFR<\/em> gene<\/b> together with vitamin B9 and B12<\/b> plays an essential role in the methylation cycle<\/b>, which is crucial for maintaining adequate homocysteine levels<\/b> and obtaining methyl groups.<\/p>\n\n\n

\n
\"Role<\/figure>\n<\/div>\n\n\n

Optimizing this methylation cycle can offer significant health benefits.<\/p>\n\n\n\n

Impact of MTHFR gene variants on health<\/h2>\n\n\n\n

The most studied variants of the MTHFR<\/em> gene<\/b> canb reduce enzyme<\/b> activity by 20-80%. Such a reduction can negatively influence health<\/b> due to impaired vitamin B9 metabolism, reduced methylation efficiency and increased homocysteine levels in the body. Especially when combined with a diet deficient in vitamin B9.<\/p>\n\n\n\n

Factors modulating the effect of the MTHFR variants<\/h2>\n\n\n\n

Diet<\/b> plays a crucial role in attenuating the impacts<\/b> of MTHFR<\/em> genetic variants. Foods rich in vitamin B9 rich foods, such as green leafy vegetables, legumes and fruits, are essential for those with reduced MTHFR enzyme activity. Additionally, folate supplements in the form of 5-methyltetrahydrofolate may be more beneficial than vitamin B9 supplements for individuals with these variants. It is also important to ensure adequate intake of vitamin B12 and B6<\/b>, which collaborate with vitamin B9 in the methylation cycle and may help to minimize the adverse effects of reduced metabolism due to decreased MTHFR enzyme activity.<\/p>\n\n\n\n

Genetic Considerations and Personalized Medicine<\/strong><\/h2>\n\n\n\n

The presence of variants in the MTHFR<\/em> gene<\/b> can increase susceptibility to various diseases<\/b>, particularly when diet and lifestyle are inadequate. For this reason, it is crucial to be informed about one's own genetic variants of the MTHFR<\/em> gene in order to focus on proper diet and monitor homocysteine levels in the blood.<\/p>\n\n\n\n

To find out your genetic variants of the MTHFR gene, test the DNA test<\/a> of ADNTRO, which includes a nutrigenetic analysis<\/a> with which you will be able to adapt your diet according to your genetics and improve your health in a personalized way.<\/p>","protected":false},"excerpt":{"rendered":"

You have probably heard of MTHFR, but do you know what role the MTHFR gene plays in health? The MTHFR gene plays a key role in the breakdown (metabolism) of folate or vitamin B9 as well as allowing the creation of a compound (methyl group) necessary for methylation. What is methylation and what role does it play in the [...]<\/p>","protected":false},"author":8,"featured_media":13880,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[42,570,18,571,569,283,20],"class_list":["post-13368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutrigenetica","tag-adntro","tag-folato","tag-genetica","tag-homocisteina","tag-mthfr","tag-nutrigenetica","tag-snp"],"yoast_head":"\nPapel del gen MTHFR en la salud<\/title>\n<meta name=\"description\" content=\"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gen-mthfr-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Papel del gen MTHFR en la salud\" \/>\n<meta property=\"og:description\" content=\"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gen-mthfr-health\/\" \/>\n<meta property=\"og:site_name\" content=\"ADNTRO\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ADNTROSPAIN\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-05T07:23:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-16T14:49:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/adntro.com\/wp-content\/uploads\/2024\/03\/DALL\u00b7E-2024-03-05-11.39.24-A-visually-captivating-composition-featuring-an-array-of-Vitamin-B9-rich-foods-such-as-dark-leafy-greens-legumes-nuts-and-fruits-artistically-susp.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1792\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Sandra Ferreiro\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@adntrospain\" \/>\n<meta name=\"twitter:site\" content=\"@adntrospain\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sandra Ferreiro\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/\"},\"author\":{\"name\":\"Sandra Ferreiro\",\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/person\/a71eca38b563da2bb60f24d7e71f7d6b\"},\"headline\":\"\u00bfQu\u00e9 papel juega el gen MTHFR en la salud?\",\"datePublished\":\"2024-03-05T07:23:00+00:00\",\"dateModified\":\"2025-06-16T14:49:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/\"},\"wordCount\":551,\"publisher\":{\"@id\":\"https:\/\/adntro.com\/de\/#organization\"},\"keywords\":[\"adntro\",\"folato\",\"gen\u00e9tica\",\"homociste\u00edna\",\"MTHFR\",\"nutrigen\u00e9tica\",\"SNP\"],\"articleSection\":[\"Nutrigen\u00e9tica\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/\",\"url\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/\",\"name\":\"Papel del gen MTHFR en la salud\",\"isPartOf\":{\"@id\":\"https:\/\/adntro.com\/de\/#website\"},\"datePublished\":\"2024-03-05T07:23:00+00:00\",\"dateModified\":\"2025-06-16T14:49:52+00:00\",\"description\":\"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.\",\"breadcrumb\":{\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/adntro.com\/es\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00bfQu\u00e9 papel juega el gen MTHFR en la salud?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/adntro.com\/de\/#website\",\"url\":\"https:\/\/adntro.com\/de\/\",\"name\":\"ADNTRO\",\"description\":\"Gen\u00e9tica, salud, nutrici\u00f3n\",\"publisher\":{\"@id\":\"https:\/\/adntro.com\/de\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/adntro.com\/de\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/adntro.com\/de\/#organization\",\"name\":\"ADNTRO Genetics\",\"url\":\"https:\/\/adntro.com\/de\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/android-chrome-512x512-2.png\",\"contentUrl\":\"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/android-chrome-512x512-2.png\",\"width\":512,\"height\":512,\"caption\":\"ADNTRO Genetics\"},\"image\":{\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ADNTROSPAIN\/\",\"https:\/\/twitter.com\/adntrospain\",\"https:\/\/www.instagram.com\/adntro_\/\",\"https:\/\/www.pinterest.es\/ADNTRO_TEAM\/_saved\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/person\/a71eca38b563da2bb60f24d7e71f7d6b\",\"name\":\"Sandra Ferreiro\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ddaa4448bc53192d65c596cd5119749fb4d7167a3b3d7931d8b0470a2021bdc3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ddaa4448bc53192d65c596cd5119749fb4d7167a3b3d7931d8b0470a2021bdc3?s=96&d=mm&r=g\",\"caption\":\"Sandra Ferreiro\"},\"description\":\"Bioinform\u00e1tica y Responsable del \u00e1rea cient\u00edfica en ADNTRO. Biotecn\u00f3loga por la Universidad Francisco de Vitoria, donde recibi\u00f3 dos becas de expediente acad\u00e9mico brillante. Estuvo trabajando en un proyecto de investigaci\u00f3n sobre la asimetr\u00eda izquierda-derecha en Newcastle, siendo premiada en la Conferencia del Centro de Investigaci\u00f3n Cardiovascular Trainees Meeting como el mejor p\u00f3ster (2018). Complet\u00f3 un m\u00e1ster en Biolog\u00eda Computacional en la Universidad Polit\u00e9cnica de Madrid. All\u00ed estudi\u00f3 las redes de interacci\u00f3n metab\u00f3lica en el microbioma de pacientes con Enfermedad de Chron y Colitis Ulcerosa en el centro de investigaci\u00f3n CBGP, centro de Excelencia Severo Ochoa (2020). Desde el 2020 es Bioinform\u00e1tica en ADNTRO donde desarrolla modelos predictivos, realiza anotaciones y an\u00e1lisis de variantes patog\u00e9nicas, investigaci\u00f3n de literatura GWAS y divulgaci\u00f3n cient\u00edfica.\",\"sameAs\":[\"https:\/\/www.linkedin.com\/in\/sandra-ferreiro-lpez-78804016a\/\"],\"url\":\"https:\/\/adntro.com\/en\/blog\/author\/sandra\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Papel del gen MTHFR en la salud","description":"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gen-mthfr-health\/","og_locale":"en_US","og_type":"article","og_title":"Papel del gen MTHFR en la salud","og_description":"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.","og_url":"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gen-mthfr-health\/","og_site_name":"ADNTRO","article_publisher":"https:\/\/www.facebook.com\/ADNTROSPAIN\/","article_published_time":"2024-03-05T07:23:00+00:00","article_modified_time":"2025-06-16T14:49:52+00:00","og_image":[{"width":1792,"height":1024,"url":"https:\/\/adntro.com\/wp-content\/uploads\/2024\/03\/DALL\u00b7E-2024-03-05-11.39.24-A-visually-captivating-composition-featuring-an-array-of-Vitamin-B9-rich-foods-such-as-dark-leafy-greens-legumes-nuts-and-fruits-artistically-susp.webp","type":"image\/webp"}],"author":"Sandra Ferreiro","twitter_card":"summary_large_image","twitter_creator":"@adntrospain","twitter_site":"@adntrospain","twitter_misc":{"Written by":"Sandra Ferreiro","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#article","isPartOf":{"@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/"},"author":{"name":"Sandra Ferreiro","@id":"https:\/\/adntro.com\/de\/#\/schema\/person\/a71eca38b563da2bb60f24d7e71f7d6b"},"headline":"\u00bfQu\u00e9 papel juega el gen MTHFR en la salud?","datePublished":"2024-03-05T07:23:00+00:00","dateModified":"2025-06-16T14:49:52+00:00","mainEntityOfPage":{"@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/"},"wordCount":551,"publisher":{"@id":"https:\/\/adntro.com\/de\/#organization"},"keywords":["adntro","folato","gen\u00e9tica","homociste\u00edna","MTHFR","nutrigen\u00e9tica","SNP"],"articleSection":["Nutrigen\u00e9tica"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/","url":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/","name":"Papel del gen MTHFR en la salud","isPartOf":{"@id":"https:\/\/adntro.com\/de\/#website"},"datePublished":"2024-03-05T07:23:00+00:00","dateModified":"2025-06-16T14:49:52+00:00","description":"Seguro que has o\u00eddo hablar de MTHFR, pero \u00bfsabes qu\u00e9 papel juega el gen MTHFR en la salud? Descubre todo sobre este gen en este art\u00edculo.","breadcrumb":{"@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/gen-mthfr-salud\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/adntro.com\/es\/"},{"@type":"ListItem","position":2,"name":"\u00bfQu\u00e9 papel juega el gen MTHFR en la salud?"}]},{"@type":"WebSite","@id":"https:\/\/adntro.com\/de\/#website","url":"https:\/\/adntro.com\/de\/","name":"ADNTRO","description":"Gen\u00e9tica, salud, nutrici\u00f3n","publisher":{"@id":"https:\/\/adntro.com\/de\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/adntro.com\/de\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/adntro.com\/de\/#organization","name":"ADNTRO Genetics","url":"https:\/\/adntro.com\/de\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/adntro.com\/de\/#\/schema\/logo\/image\/","url":"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/android-chrome-512x512-2.png","contentUrl":"https:\/\/adntro.com\/wp-content\/uploads\/2021\/08\/android-chrome-512x512-2.png","width":512,"height":512,"caption":"ADNTRO Genetics"},"image":{"@id":"https:\/\/adntro.com\/de\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ADNTROSPAIN\/","https:\/\/twitter.com\/adntrospain","https:\/\/www.instagram.com\/adntro_\/","https:\/\/www.pinterest.es\/ADNTRO_TEAM\/_saved\/"]},{"@type":"Person","@id":"https:\/\/adntro.com\/de\/#\/schema\/person\/a71eca38b563da2bb60f24d7e71f7d6b","name":"Sandra Ferreiro","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/adntro.com\/de\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/ddaa4448bc53192d65c596cd5119749fb4d7167a3b3d7931d8b0470a2021bdc3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ddaa4448bc53192d65c596cd5119749fb4d7167a3b3d7931d8b0470a2021bdc3?s=96&d=mm&r=g","caption":"Sandra Ferreiro"},"description":"Bioinform\u00e1tica y Responsable del \u00e1rea cient\u00edfica en ADNTRO. Biotecn\u00f3loga por la Universidad Francisco de Vitoria, donde recibi\u00f3 dos becas de expediente acad\u00e9mico brillante. Estuvo trabajando en un proyecto de investigaci\u00f3n sobre la asimetr\u00eda izquierda-derecha en Newcastle, siendo premiada en la Conferencia del Centro de Investigaci\u00f3n Cardiovascular Trainees Meeting como el mejor p\u00f3ster (2018). Complet\u00f3 un m\u00e1ster en Biolog\u00eda Computacional en la Universidad Polit\u00e9cnica de Madrid. All\u00ed estudi\u00f3 las redes de interacci\u00f3n metab\u00f3lica en el microbioma de pacientes con Enfermedad de Chron y Colitis Ulcerosa en el centro de investigaci\u00f3n CBGP, centro de Excelencia Severo Ochoa (2020). Desde el 2020 es Bioinform\u00e1tica en ADNTRO donde desarrolla modelos predictivos, realiza anotaciones y an\u00e1lisis de variantes patog\u00e9nicas, investigaci\u00f3n de literatura GWAS y divulgaci\u00f3n cient\u00edfica.","sameAs":["https:\/\/www.linkedin.com\/in\/sandra-ferreiro-lpez-78804016a\/"],"url":"https:\/\/adntro.com\/en\/blog\/author\/sandra\/"}]}},"_links":{"self":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/13368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/comments?post=13368"}],"version-history":[{"count":4,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/13368\/revisions"}],"predecessor-version":[{"id":17442,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/posts\/13368\/revisions\/17442"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/media\/13880"}],"wp:attachment":[{"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/media?parent=13368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/categories?post=13368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/adntro.com\/en\/wp-json\/wp\/v2\/tags?post=13368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}