{"id":10386,"date":"2023-04-14T08:23:00","date_gmt":"2023-04-14T06:23:00","guid":{"rendered":"https:\/\/adntro.com\/?p=10386"},"modified":"2025-07-28T08:31:39","modified_gmt":"2025-07-28T06:31:39","slug":"intolerancia_gluten_lactosa_fructosa","status":"publish","type":"post","link":"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/","title":{"rendered":"Gluten, lactose and fructose intolerance"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"10386\" class=\"elementor elementor-10386\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4a9c7e6e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4a9c7e6e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2e5cb711\" data-id=\"2e5cb711\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d7efb0 elementor-widget elementor-widget-text-editor\" data-id=\"6d7efb0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<!-- wp:paragraph -->\n<p class=\" translation-block\"><b>Food intolerances are an adverse reaction of the body to certain foods or ingredients consumed in the diet<\/b>. Unlike food allergies, food intolerances usually involve a milder response and can be caused by different factors. Examples include a lack of an enzyme needed to digest a food or moderate activation of the immune system. <b>Common food intolerances include gluten, lactose and fructose intolerance<\/b>.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>Food intolerances can cause a wide variety of symptoms. The most common symptoms are nausea, abdominal pain, diarrhea, constipation, bloating, gas, fatigue, headaches and skin rashes. Although these symptoms are usually less severe than those of a food allergy, <strong>can significantly affect a person's quality of life.<\/strong>.\u00a0<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>In the following, we will detail the <a href=\"https:\/\/adntro.com\/en\/genetic-intolerance-test\/\">gluten, lactose and fructose intolerance<\/a>. These three nutrients are found in different foods and are the three most common types of intolerance.<\/p>\n<!-- \/wp:paragraph --><!-- wp:image {\"align\":\"center\",\"id\":10387,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"711\" height=\"355\" class=\"wp-image-10387\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image.png\" alt=\"Gluten, dairy products and fructose\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image.png 711w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-300x150.png 300w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-18x9.png 18w\" sizes=\"(max-width: 711px) 100vw, 711px\" \/><\/figure>\n<!-- \/wp:image --><!-- wp:heading -->\n<h2 class=\"wp-block-heading\"><strong>Gluten intolerance<\/strong><\/h2>\n<!-- \/wp:heading --><!-- wp:paragraph -->\n<p>Gluten is a protein present in certain cereals, such as wheat, barley and rye. In individuals with gluten intolerance, its consumption can cause damage to the lining of the small intestine, as well as other symptoms such as abdominal discomfort, diarrhea, fatigue, and growth disturbances in the case of children.<\/p>\n<!-- \/wp:paragraph --><!-- wp:image {\"align\":\"center\",\"id\":10388,\"width\":263,\"height\":263,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" class=\"wp-image-10388\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-1.png\" alt=\"Gluten intolerance - Genetic predisposition\" width=\"263\" height=\"263\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-1.png 205w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-1-150x150.png 150w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-1-12x12.png 12w\" sizes=\"(max-width: 263px) 100vw, 263px\" \/><\/figure>\n<!-- \/wp:image --><!-- wp:paragraph -->\n<p class=\" translation-block\"><b>There are varying degrees of gluten intolerance<\/b>. The most severe is <b>celiac disease<\/b> (CD), a chronic inflammatory pathology that occurs as a result of this gluten intolerance. When ingesting this protein, the immune system reacts as if it were a foreign substance and damages the lining of the small intestine. This triggers the infiltration of inflammatory cells into the intestine. This can interfere with nutrient absorption and cause severe villi damage to the intestinal mucosa.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>Other cases of gluten intolerance are called gluten intolerance. <strong>non-celiac gluten sensitivity<\/strong> (NCGS).  People with this condition may experience symptoms similar to those of celiac disease, such as abdominal pain, diarrhea and fatigue. The difference between the two conditions lies in changes in the lining of the small intestine (does not occur in people with NCGS). It is thought that this sensitivity may be related to an abnormal immune response to gluten, although the specific mechanisms associated with its occurrence are not yet known.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p class=\" translation-block\"><b>Gluten intolerance has a strong genetic predisposition<\/b>, which means that certain genes can increase the risk of developing this condition. The most commonly associated haplotypes are <b>HLA-DQ2<\/b> and <b>HLA-DQ8<\/b>.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>These genetic markers are located on chromosome 6 and are involved in the presentation of proteins to the immune system. Most people with CD, about 95%, have a variant of this gene known as DQ2.5, which is considered the main genetic risk factor for the disease. The remaining 5% usually have HLA-DQ8.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p class=\" translation-block\"><b>These markers are found in about 30% in the apparently healthy general population, so having these markers is a necessary, but not determinant, condition for developing gluten intolerance<\/b>. In people with NCGS, the frequency of these markers is higher than in the general population, but much lower than in CD, around 50%.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p class=\" translation-block\">In summary, gluten can cause problems in some people due to an abnormal immune response that can lead to damage to the small intestine and other symptoms. <b>If gluten intolerance or sensitivity is suspected, it is important to talk to a doctor and nutritionist to make an accurate diagnosis with all recommended tests, including genetic predisposition<\/b>.<\/p>\n<!-- \/wp:paragraph --><!-- wp:heading -->\n<h2 class=\"wp-block-heading\"><strong>Lactose intolerance<\/strong><\/h2>\n<!-- \/wp:heading --><!-- wp:paragraph -->\n<p>Lactose is a carbohydrate found naturally in milk and milk products. Those who are lactose intolerant cannot digest this sugar properly due to a deficiency in the production of the enzyme lactase. As a result, they may experience symptoms such as abdominal discomfort, bloating, and diarrhea after eating foods containing this sugar.<\/p>\n<!-- \/wp:paragraph --><!-- wp:image {\"align\":\"center\",\"id\":10389,\"width\":256,\"height\":256,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" class=\"wp-image-10389\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-2.png\" alt=\"Lactose intolerance - Genetic predisposition\" width=\"256\" height=\"256\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-2.png 254w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-2-150x150.png 150w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-2-12x12.png 12w\" sizes=\"(max-width: 256px) 100vw, 256px\" \/><\/figure>\n<!-- \/wp:image --><!-- wp:paragraph -->\n<p class=\" translation-block\"><b>It is known that lactose intolerance has a clear genetic predisposition associated with the <em>MCM6<\/em> gene<\/b>. This gene is located near the lactase gene on chromosome 2. The most common variant of  the <em>MCM6<\/em> gene, called -13910 C\/T, has been strongly associated with lactase production in adulthood and thus with the ability to digest lactose.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p class=\" translation-block\">This variant has been found to <b>control lactase production in humans<\/b>. This variant has been associated with increased lactase production in adulthood, allowing people to digest the lactose in dairy products. On the contrary, not presenting this variant predisposes to a lower production of lactase, and therefore, a lower capacity to digest lactose.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p class=\" translation-block\">Therefore, this variant of the <b><em>MCM6<\/em> gene  has been used as a useful genetic marker to predict a person's ability to digest lactose, and thus identify lactose intolerance<\/b>.<\/p>\n<!-- \/wp:paragraph --><!-- wp:heading -->\n<h2 class=\"wp-block-heading\"><strong>Fructose intolerance<\/strong><\/h2>\n<!-- \/wp:heading --><!-- wp:paragraph -->\n<p>Fructose is a carbohydrate present both in various fruits and in processed products such as soft drinks, syrups and prepared foods. People suffering from fructose intolerance may experience abdominal discomfort, bloating and diarrhea after eating foods containing this type of sugar.<\/p>\n<!-- \/wp:paragraph --><!-- wp:image {\"align\":\"center\",\"id\":10390,\"width\":303,\"height\":303,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-10390\" src=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-3.png\" alt=\"Fructose intolerance - Genetic predisposition\" width=\"303\" height=\"303\" srcset=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-3.png 283w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-3-150x150.png 150w, https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image-3-12x12.png 12w\" sizes=\"(max-width: 303px) 100vw, 303px\" \/><\/figure>\n<!-- \/wp:image --><!-- wp:paragraph -->\n<p class=\" translation-block\"><b>There are different types of fructose intolerance<\/b>. There is a <b>genetic disease, called hereditary fructose intolerance<\/b> (IHF), that affects the body's ability to process and metabolize fructose. IHF is caused by mutations  in the <em>ALDOB<\/em> gene, which provides instructions for the production of the enzyme aldolase B needed to break down fructose in the liver.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>These mutations can affect the production, stability or activity of the enzyme, leading to partial or total deficiency of the enzyme. This leads to the accumulation of fructose and its metabolites in the body, causing the aforementioned symptoms.<\/p>\n<!-- \/wp:paragraph --><!-- wp:spacer {\"height\":\"33px\"} -->\n<div class=\"wp-block-spacer\" style=\"height: 33px;\" aria-hidden=\"true\">\u00a0<\/div>\n<!-- \/wp:spacer --><!-- wp:paragraph -->\n<p>If any food intolerance is suspected, it is important to consult a doctor and nutritionist to obtain an accurate diagnosis along with appropriate recommendations for adapting the diet.<\/p>\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n<p>Now <strong>you can find out your genetic predisposition to gluten, lactose and fructose intolerance along with many other nutritional traits with the <a href=\"https:\/\/adntro.com\/en\/genetic-nutritional-test-report\/\">nutrigenetic test<\/a> by ADNTRO<\/strong>What are you waiting for to get to know yourself better?\u00a0<\/p>\n<!-- \/wp:paragraph -->\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Food intolerances are an adverse reaction of the body to certain foods or ingredients consumed in the diet. Unlike food allergies, food intolerances usually involve a milder response and can be caused by different factors. Some examples are the lack of an enzyme needed to digest a food [...]<\/p>","protected":false},"author":16,"featured_media":10387,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[42,474,18,473,477,476,475,472,44,22,20],"class_list":["post-10386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutrigenetica","tag-adntro","tag-fructosa","tag-genetica","tag-gluten","tag-intolerancia-a-la-fructosa","tag-intolerancia-a-la-lactosa","tag-intolerancia-al-gluten","tag-intolerancias","tag-lactosa","tag-predisposicion-genetica","tag-snp"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Intolerancia al gluten lactosa y fructosa<\/title>\n<meta name=\"description\" content=\"Las intolerancias alimentarias tienen un componente gen\u00e9tico. Descubre todo acerca de la intolerancia al gluten, lactosa y fructosa.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intolerancia al gluten lactosa y fructosa\" \/>\n<meta property=\"og:description\" content=\"Las intolerancias alimentarias tienen un componente gen\u00e9tico. Descubre todo acerca de la intolerancia al gluten, lactosa y fructosa.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/\" \/>\n<meta property=\"og:site_name\" content=\"ADNTRO\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ADNTROSPAIN\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-14T06:23:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-28T06:31:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/adntro.com\/wp-content\/uploads\/2023\/04\/image.png\" \/>\n\t<meta property=\"og:image:width\" content=\"711\" \/>\n\t<meta property=\"og:image:height\" content=\"355\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Marta Alonso\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@adntrospain\" \/>\n<meta name=\"twitter:site\" content=\"@adntrospain\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Marta Alonso\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/intolerancia_gluten_lactosa_fructosa\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/\"},\"author\":{\"name\":\"Marta Alonso\",\"@id\":\"https:\/\/adntro.com\/de\/#\/schema\/person\/7960f3284c722ff93d15d2e312cc778e\"},\"headline\":\"Intolerancia al gluten, lactosa y fructosa\",\"datePublished\":\"2023-04-14T06:23:00+00:00\",\"dateModified\":\"2025-07-28T06:31:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/\"},\"wordCount\":1129,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/adntro.com\/de\/#organization\"},\"keywords\":[\"adntro\",\"fructosa\",\"gen\u00e9tica\",\"gluten\",\"intolerancia a la fructosa\",\"intolerancia a la lactosa\",\"intolerancia al gluten\",\"intolerancias\",\"lactosa\",\"predisposici\u00f3n gen\u00e9tica\",\"SNP\"],\"articleSection\":[\"Nutrigen\u00e9tica\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/intolerancia_gluten_lactosa_fructosa\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/adntro.com\/en\/blog\/nutrigenetics\/gluten_gluten_lactose_fructose_intolerance\/\",\"url\":\"https:\/\/adntro.com\/es\/blog\/nutrigenetica\/intolerancia_gluten_lactosa_fructosa\/\",\"name\":\"Intolerancia al gluten lactosa y fructosa\",\"isPartOf\":{\"@id\":\"https:\/\/adntro.com\/de\/#website\"},\"datePublished\":\"2023-04-14T06:23:00+00:00\",\"dateModified\":\"2025-07-28T06:31:39+00:00\",\"description\":\"Las intolerancias alimentarias tienen un componente gen\u00e9tico. 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Dietista-nutricionista por la Universidad Aut\u00f3noma de Madrid (UAM, 2011-2015) y doctora en Nutrigen\u00f3mica y Nutrici\u00f3n Personalizada por la Universidad de las Islas Baleares (UIB, 2018-2022). Cuenta con un M\u00e1ster en Biomol\u00e9culas y Din\u00e1mica Celular (UAM, 2015-2016), as\u00ed como otro en Nutrigen\u00f3mica y Nutrici\u00f3n Personalizada (UIB, 2016-2017). Adem\u00e1s, es experta universitaria en gen\u00e9tica m\u00e9dica y gen\u00f3mica (UCAM, 2019) y ha realizado numerosos cursos de formaci\u00f3n en materia de gen\u00f3mica nutricional en centros de referencia. Cuenta con amplia experiencia como investigadora en el campo de la nutrici\u00f3n de precisi\u00f3n y ciencias \u00f3micas, participando en proyectos de investigaci\u00f3n tanto nacionales como internacionales. 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